TP53 and alcohol drinking: Since ICB response plays an important role in immune checkpoint therapy, we further analyzed the correlation between risk score and ICB response signature (Figures 7H, J) and found that among them, Systemic lupus erythematosus, Base excision repair, p53 signaling pathway, Proteasome, and Cytokine-cytokine receptor interaction were significantly positively correlated, while significantly negatively correlated with Alcoholism and Spliceosome.