(93) reported that circ_7042 could prevent the IDD progression through inhibiting NP cells apoptosis, senescence and ECM degradation by absorption of miR-369-3p/BMP2/PI3K/Akt axis. Apart from sponging miRNAs, the interaction of different circRNAs may have impacts on the downstream pathway, which urgently needs more evidence to further verify. The gene discussed is BMP2; the disease is intervertebral disk degenerative disorder.