Similarly, other studies demonstrated that cicrRNAs also afforded protection against IDD development, mainly including circRNA-CIDN/miR-34a-5p/SIRT1 (83), circGLCE/miR-587/STAP1 (84) and circARL15/miR-431-5p/DISC1 (85) pathway. This evidence concerns the gene SIRT1 and intervertebral disk degenerative disorder.