At the present, an increasing number of lncRNAs have been found to involve in the pathological process of IDD, such as lncRNA SNHG6/miR-101-3p (77), lncRNA MIR155HG/miR-223-3p (78) and lncRNA H19/miR-139-3p/CXCR4/NF-κB (79) axes. The gene discussed is NFKB1; the disease is intervertebral disk degenerative disorder.