GPHB5 and polycystic ovary syndrome: The results showed that the best cut-off value for circulating GPHB5 to predict IR was 3.51 μg/L (sensitivity 70.1%, specificity 87.1%, and AUC 0.87; Figure 6G), and to predict PCOS was 2.37 μg/L (sensitivity 95.4%, specificity 58.8%, and AUC 0.82, Figure 6H).