To further reveal the association between GPHB5 and IR and PCOS, we divided the circulating GPHB5 concentration into four titers (tertile 1,< 2.17 μg/L; tertile 2, 2.17 to 3.16 μg/L; tertile 3, 3.16 to 3.95 μg/L; tertile 4, > 3.95 μg/L for IR and tertile 1,< 2.35 μg/L; tertile 2, 2.35 to 3.17 μg/L; tertile 3, 3.17 to 3.96 μg/L; tertile 4, > 3.96 μg/L for PCOS). This evidence concerns the gene GPHB5 and polycystic ovary syndrome.