GPHB5 and polycystic ovary syndrome: We first analyzed the distribution range of circulating GPHB5 concentrations in all study populations and found that the GPHB5 concentration range of normal controls was mainly 1.0 - 3.5 μg/L, that of the IR population was 3.0 - 5.5 μg/L, and that of the PCOS individuals was 2.5 - 5.5 μg/L (Figures 5A–C).