GPHB5 and polycystic ovary syndrome: When the circulating GPHB5 concentration was in tertiles 2, 3 and 4, the odds ratios (ORs) of having IR and PCOS were 13.2 (95% confidence interval (CI), 2.60; 2.74), 34 (95% CI, 3.44; 3.55) and 251.6 (95% CI, 4.59; 4.82) for IR (Figure 6E), and 12.10 (95% CI, 2.71; 2.83), 17.3 (95% CI, 3.44; 3.64) and 135 (95% CI, 4.59; 4.80) for PCOS (Figure 6F).