The likely pathogenic mutations of CLL were <i>SETD2</i>, <i>NOTCH1</i>, <i>SF3B1</i>, and <i>PTPN11</i>, while the likely pathogenic mutations related with the MEILT were <i>TET2</i> and <i>ZRSR2</i>. The gene discussed is SF3B1; the disease is B-cell chronic lymphocytic leukemia.