ITGAM and neoplasm: In mice, MDSCs are defined by the expression of CD11b+ Gr1+ and can be further divided into Ly6C−Ly6G+G-MDSCs and Ly6C+Ly6G−M-MDSCs (mononuclear-MDSCs).13We took the bone marrow cells and spleen cells of the tumor-bearing mice and the control group for flow analysis and found that MDSCs from the bone marrow and spleen of the tumor-bearing mice were expanded (Fig. 1A).