TSC1 and neoplasm: Clustering analysis of BMDCs and MDSC-DCs in the genes of mTOR signaling pathway found that tumor suppressor factors such as Pten, Tsc1, Ddit4, mtor, Rptor, and other genes involved in controlling the activity of rapamycin complex 1 (mTORC1) were found in MDSCs-DCs and are all down-regulated.