Selecting the more common chemokines and their receptors in the cytokine–cytokine receptor interaction pathway, it can be found that the gene expressions of chemokines and their receptors in MDSC-DCs of tumor-bearing mice are generally up-regulated compared with BMDCs; especially, CCL5 and its receptors CCR1, CCR3, and CCR5 were all up-regulated. This evidence concerns the gene CCL5 and neoplasm.