Ubiquitin/ISG15-conjugating enzyme E2L6 (UBE2L6) is an E2 ubiquitin/ISG15-binding enzyme that has a decisive function in inhibiting cell proliferation and xenograft tumour advancement by interacting with E3 ubiquitin ligase to target c-Myc for proteasomal disintegration [75]. This evidence concerns the gene MYC and neoplasm.