TNF and Parkinson disease: Mucuna pruriens was also found to have neuroprotective effect and immunosuppressive properties [186], and it possess a variety of pharmacological properties including antioxidant and anti-Parkinsonism effects; studies have shown that Mucuna pruriens significantly inhibited the release of inflammatory mediators including nitric oxide (NO), IL-1β, IL-6, and TNF-α in LPS-induced BV2 microglial cells [187].