More importantly, high expression of VEGF, IL-8, IL-10, and positive PIK3CA and RIP2, were also risk factors for the prognosis of DLBCL patients, and the possible mechanisms are as follows: firstly, angiogenesis is extremely important for the growth, malignancy and metastasis of DLBCL. Here, VEGFA is linked to diffuse large B-cell lymphoma.