In 2013, Alejandria et al. [118] conducted a meta-analysis in which 10 studies of IVIG treatment for sepsis (n = 1430) showed that the 28–180-day mortality rates were 29.6% in the IVIG group and 36.5% in the placebo group (RR = 0.81; 95% CI 0.70–0.93), whereas other 7 studies using IgM-enriched IVIG (IVIGM) (n = 528) showed that the 28–60-day mortality rates were 24.7% in the IVIGM group and 37.5% in the placebo group (RR = 0.66; 95% CI 0.51–0.85); however, it should be noted that both meta-analyses of IVIG and IVIGM treatment had moderate-to-high risk of bias. Here, CD40LG is linked to Sepsis.