CD8A and neoplasm: Since tumor hypoxia is one of the main problems faced by oxygen‐dependent PDT, the combination with nonoxygen‐dependent therapies such as immunotherapy is a promising strategy.[96] Furthermore, PDT has shown the ability to induce antitumor immunity like induction of ICD and release of tumor‐associated antigens (TAAs) during cancer cells' destruction, leading to the activation and proliferation of CD8+ T lymphocytes.