An iron‐based nMOFs loaded with DOX and glucose oxidase (GOx) were designed based on the “ROS–ferroptosis–glycolytic regulation” strategy (Figure 3a).[119] Fe3+ removes excess GSH in tumor cells and downregulates glutathione peroxide 4 (GPX4) to induce ferroptosis, which can combine with DOX to induce ICD in tumor cells and release TAAs to initiate antitumor immunity. Here, GPX4 is linked to neoplasm.