Zou and co‐workers reported a ZIF‐8‐based core–shell nanoplatform for impairing therapeutic effects including chemotherapy and advancing ICB therapy.[76] By embedding with catalase and DOX, the nMOFs work as an oxygen generator and drug reservoir that possesses the ability to alleviate tumor hypoxia, which is highly correlated with the expression of PD‐L1. This evidence concerns the gene CD274 and neoplasm.