Tumor autoantigens generated after photothermal ablation could show vaccine‐like functions in combination with immune adjuvants to effectively motivate systemic antitumor immunity, and the immunomodulation mediated by 1 MT on immunosuppressive IDO could significantly increase the ratio of effector T cells (CD8+/CD4+ T cells) to immunosuppressive Tregs, thereby preventing immune evasion, and consequently promoting the secretion of proinflammatory factors Interferon γ (IFN‐γ) and IL‐6, and effectively activate systemic immunity. The gene discussed is IDO1; the disease is neoplasm.