fabricated the amphiphilic polymer PEG–polyphenol and lanthanide‐doped radiosensitizer‐based MPNs and Mn2+ were introduced to activate the STING pathway.[149] Upon X‐ray irradiation, MPNs promoted cancer cells’ cytosolic double‐stranded DNA (dsDNA) release and Mn2+ facilitated the recognition of cytosolic dsDNA by cGAS, triggering the activation of the STING pathway in both cancer cells and DCs to optimize RT (Figure 8d). This evidence concerns the gene STING1 and cancer.