CGAS and cancer: fabricated the amphiphilic polymer PEG–polyphenol and lanthanide‐doped radiosensitizer‐based MPNs and Mn2+ were introduced to activate the STING pathway.[149] Upon X‐ray irradiation, MPNs promoted cancer cells’ cytosolic double‐stranded DNA (dsDNA) release and Mn2+ facilitated the recognition of cytosolic dsDNA by cGAS, triggering the activation of the STING pathway in both cancer cells and DCs to optimize RT (Figure 8d).