PD‐L1 has previously been shown to be secreted out of tumor cells via EVs.[17] We showed that the cytosolic PD‐L1‐GFP puncta indeed exhibited strong colocalization with various MVBs or EV markers (e.g., CD63, TSG101, and Rab27a), in PD‐L1‐GFP‐expressing cells (Figure 2A). Here, TSG101 is linked to neoplasm.