Through analysis of single‐cell transcriptome data from Luo et al.,[11] we identified increased Gsdmd expression in the VSMCs of aortic aneurysm and dissection (AAD) tissues from mice treated with a high‐fat diet and angiotensin (Ang) II, compared to those from aortic tissues from control mice (Figure 1A). Here, GSDMD is linked to aortic aneurysm.