GSDMD releases inflammatory cytokines, such as interleukin (IL)‐1β and IL‐18[36] and has been reported in many cardiovascular diseases such as atherosclerosis,[37] ischemic heart disease,[38] and diabetic cardiomyopathy.[39] To date, numerous studies have been conducted on GSDMD in macrophages; however, the role of GSDMD in VSMCs, which are important components of vessels, has not yet been elucidated. The gene discussed is IL18; the disease is atherosclerosis.