ER stress, particularly the upregulation of CHOP, plays an important role in VSMCs degeneration and AAA progression.[25] CHOP deficiency can suppress 3‐aminopropionitrile fumarate‐induced thoracic aortic aneurysm/dissection.[26] On this basis, we hypothesized that GSDMD could cause ER stress in VSMCs, upregulate CHOP, and promote the transcription of ODC1. Here, DDIT3 is linked to thoracic aortic aneurysm.