APOE and triple-A syndrome: To determine whether ablation of VSMC‐derived GSDMD ameliorated AAA, we generated VSMC‐restricted GSDMD‐deficient mice and crossed VSMC‐restricted GSDMD‐deficient mice with the apolipoprotein E (ApoE) knockout mice; that is, GSDMDfl/flSM22Cre+/−, GSDMDfl/fl, GSDMDfl/flSM22Cre+/−ApoE−/−, and GSDMDfl/flApoE−/− mice (Figure S1B, Supporting Information).