In addition, hypoxia can induce angiogenesis in MI tissue by promoting the secretion of VEGF, whereas ROS leads to insufficient angiogenesis by inhibiting VEGF production.[14] Although endogenous antioxidant systems such as glutathione peroxidase 4 (GPx4) can effectively eliminate ROS in cardiomyocytes, the initial burst of ROS overwhelms and destroys the antioxidant system in cardiomyocytes.[15] Correspondingly, MI tissue has a weak antioxidant capacity and cannot resist the damage caused by ROS. The gene discussed is GPX4; the disease is myocardial infarction.