PTPN11 missense and short insertion‒deletion variants have been reported in 58 of 1,030 (6%) melanoma samples in the COSMIC database (including two of the variants we describe in this study), and PTPN11 has recently been implicated in the pathogenesis of BRAF-wild-type melanoma (Hill et al., 2019). This evidence concerns the gene BRAF and melanoma.