In addition, calorie restriction delays theage-related or diabetes-related loss of DRD2 in rat brain (Roth et al., 1984; Thanos et al.,2008; de Leeuw van Weenen et al., 2011).Our results are consistent with the above studies showing that the molecular mechanisms offasting on depression may be closely linked to dopamine. The gene discussed is DRD2; the disease is major depressive disorder.