This profile shows similarities with CRFR1 antagonists, which display efficacy in exploration-based models of anxiety under stressed, but not in nonstressed testing conditions (Okuyama et al., 1999; Gilligan et al., 2000; Griebel et al., 2002; Heinrichs et al., 2002; Zorrilla et al., 2002; Lelas et al., 2004; Ising et al., 2007; Zorrilla and Koob, 2010). Here, CRHR1 is linked to Anxiety.