While this is in line with previous report that exogenous intra-CeA administration of PACAP elevates plasma CORT levels (Iemolo et al., 2016); it also suggests that the reversal of the CSDS-induced heightened anxiety-like behavior is not a consequence of its effects on the HPA axis, as PAC1R knock-down did not “normalize” CORT levels in CSDS animals, but rather a cumulative effect of CSDS and CeA PAC1R knock-down was observed. The gene discussed is ADCYAP1; the disease is Anxiety.