Through intratracheal instillation of the Delta variant SARS-CoV-2 virus (2 × 105 PFU) in human ACE2-transgenic mice (hACE2), we developed ARDS models that mimic severe COVID-19.22 Following that, we investigate TP lipo’s efficacy against ARDS induced by SARS-CoV-2 Delta variant infection in vivo. Here, ACE2 is linked to infection.