CCL3 and COVID-19: Additionally, TP lipo could reduce neutrophil infiltration by downregulating the gene expression of Icam1 (neutrophil adhesion) and Vegfa (angiogenesis).46,47 TP lipo might relieve endotheliopathy and inflammation in long COVID-19 patients by targeting IL-6 and ICAM-1.48 Collectedly, Neutrophil-Ccl3 cells are essential in responding to FA-S-induced ARDS, and TP lipo can target them well and effectively alleviate hyperinflammation.