There is a reported uncontrolled inflammatory response to COVID-19, as well as NF-B and p38 MAPK activation triggered by the virus.27,60 Our results showed that TP lipo suppressed the phosphorylation of NF-κB and p38 MAPK in SARS-CoV-2-infected cells (Fig. 2e), indicating that TP lipo could ameliorate hyperinflammation by targeting upregulated proinflammatory pathways. Here, NFKB1 is linked to COVID-19.