The percentage of FoxP3+ Tregs among total CD4+ T cells is strongly heterogeneous and higher in lung tumors (median = 14%) compared with those at distant sites, i.e., non-tumor distant lung (NTDL, median = 5%), lymph nodes (LN, median = 8%) and blood (median = 7%) samples from NSCLC patients (Fig. 3a), suggesting an active recruitment and/or local proliferation of Tregs within the tumor. The gene discussed is CD4; the disease is neoplasm.