Despite circulatory Gal-3 levels are augmented in AF patients undergoing radiofrequency catheter ablation, Gal-3 is not useful for predicting rhythm outcome, because that increase could be driven by cardiometabolic comorbidities and not by heart rhythm, so further studies are necessary to establish if Gal-3 could predict recurrence33. Here, LGALS3 is linked to atrial fibrillation.