In terms of tau pathology, while a recent CSF study revealed that current BP had a significant positive association with tau level [17] and a PET study showed that systolic BP (SBP) synergistically interacted with Aβ on tau deposition [25], other studies reported that a history of hypertension was not related to CSF tau level or tau deposition on PET [19, 24]. This evidence concerns the gene MAPT and hypertensive disorder.