IL6 and juvenile polyposis syndrome: In this systematic review and meta-analysis of 30 DTA studies, we evaluated the diagnostic value of both serum and synovial fluid IL-6 tests for detecting PJI after hip and knee replacements, and found that synovial fluid IL-6 might be preferentially prescribed for detecting PJI after hip and knee replacements owing to its higher sensitivity, specificity, DOR, and diagnostic accuracy.