A seven-genes signature model was established by LASSO regression, which included capping actin protein, gelsolin like (CAPG), Fanconi anemia complement group D2 (FANCD2), heme oxygenase-1(HMOX1), heat shock protein beta-1(HSPB1), ribonucleotide reductase regulatory subunit M2(RRM2), SLC1A5, and six-transmembrane epithelial antigen of prostate 3 (STEAP3) (Fig. 1D). This evidence concerns the gene RRM2 and anemia (phenotype).