Variants in PGM3 were first assumed to be responsible for autosomal recessive forms of hyper IgE syndrome, patients with CID/SCID phenotype and mutated PGM3 are reported in the literature [30–33], mainly manifesting as facial dysmorphisms, skeletal abnormalities, neurologic disorders, renal disorders, and gastrointestinal complications, and less frequently congenital heart disorders, and recurrent respiratory tract infections. Here, PGM3 is linked to Respiratory tract infection.