Representative western blotting images (Fig. 8A) and fold changes in the relative densitometric values of CASP3 and EGFR are shown in Fig. 8B, C. Compared with the WT group, the expression of EGFR and CASP3 in 3 × Tg-AD mice increased significantly (p < 0.05). This evidence concerns the gene EGFR and Alzheimer disease.