PRNP and neurodegenerative disease: Indeed, α-cleavage and PrPC shedding release N-terminal fragments able to bind and neutralize neurotoxic oligomers, while at the same time reducing FL-PrPC on the cell membrane and, thus, its pathological consequences, such as PrPSc propagation in TSEs and oligomer-associated toxic signaling in other neurodegenerative diseases (6, 53).