ALDH1A1 and cancer: In this context, and in line with these results, our research group has already demonstrated that the tumor budding area, when compared to the area outside the budding, has a higher rate of cell proliferation (20) and a higher expression of cancer stem cell-like marker ALDH1 (21), reinforcing the hypothesis that tumor budding is a phenomenon associated with the biological behavior of the OSCC, especially that related with tumor progression and metastasis.