DPYSL2 and rheumatoid arthritis: Here, we demonstrated that (i) the central sensitization of rheumatoid arthritis was closely related to arthritis chronic pain, (ii) NAR suppressed spinal central sensitization in collagen-induced RA chronic pain, and (iii) the inhibition of RA central sensitization by NAR was mainly manifested by its inhibition of spinal neuronal CRMP2 phosphorylation.