By contrast, a recent study led by Kiani Shabestari et al. showed that genetic ablation of microglia via deletion of the CSF1R enhancer FIRE induces a shift from parenchymal amyloid plaques to cerebral amyloid angiopathy in 5xFAD mice, which is accompanied by brain calcification and hemorrhages [207]. This evidence concerns the gene CSF1R and cerebral amyloid angiopathy.