Moreover, in the pan-cancer analysis, these 39 genes, including five tumour microenvironment genes (Fig. 4B), five immune checkpoints (Fig. 4C), 11 T-cell receptors (Fig. 4D), and 18 T-effector and IFNγ pathway-relevant genes (Fig. 4E), were significantly up-regulated in the SpHe-comut+ group compared with the SpHe-comut− group. This evidence concerns the gene IFNG and neoplasm.