In systemic sclerosis, anti-CENP-B antibodies showed a strong association (p=0.0001) with lcSSc (81 patients) and an AUC of 0.902; in dcSSc (52 patients), AUC for anti-Scl70 was 0.874 (p=0.001). The gene discussed is CENPB; the disease is systemic sclerosis.