For this reason, some specific ANA are included in the classification criteria of CTD, such as anti-Ro60 for pSS [1], anti-topoisomerase I (also known as Scl70), anti-centromere B protein (CENP-B), and anti-RNA polymerase III (RNA pol III) for SSc [2]; anti-histidyl tRNA synthetase (Jo1) for IIM [3]; anti-U1RNP for MCTD [4]; and anti-dsDNA as well as anti-Sm for SLE [5]. This evidence concerns the gene CENPB and mixed connective tissue disease.