In addition, an increased proinflammatory state associated with HDP [9, 10] and GDM [11, 12] has been described, and in that respect, our group has observed an angiogenic imbalance, characterized by an increased soluble fms-like tyrosine kinase–1/placental growth factor (sFlt-1/PlGF) ratio, as a valid predictor of the development of HDP in women with GDM, as well as its association with obstetric and perinatal complications [13]. The gene discussed is PGF; the disease is gestational diabetes.