In relation to angiogenic factors, evidence supports an angiogenic imbalance, characterized by greater concentrations of sFlt-1, lower PlGF levels and, particularly, a higher sFlt-1/PlGF ratio correlated with the risk of developing preeclampsia in pregnant women [9, 46–48] as well as those with preexisting diabetes [49, 50]. The gene discussed is PGF; the disease is preeclampsia.