ICOS and breast cancer: Clearly, GATA3 was negatively correlated with CTL signature gene (IL2, CD8A, CCL5, GZMA, PRF1, IFNG, PTPRC, GZMM, RAB27A, XCL1, ICOS, TBX21, GZMB, GNLY, and IL12A) in breast cancer (Fig. 1D).