GATA3 conducts as a master transcription factor for the differentiation of Th2 cells to activate Th2 cytokine expression in IL-4 dependent or independent pathway [37], and has been used to define Th2 cell population [38].To investigate the correlation between Th2 cells and tumor-immune landscape, we first divided the METABRIC samples into Th2-high and Th2-low groups based on GATA3 expression, and delineated the pattern of TILs in the two groups based on gene expression profile with CIBERSORT algorithm. This evidence concerns the gene IL4 and neoplasm.