GATA3 and neoplasm: GATA3 conducts as a master transcription factor for the differentiation of Th2 cells to activate Th2 cytokine expression in IL-4 dependent or independent pathway [37], and has been used to define Th2 cell population [38].To investigate the correlation between Th2 cells and tumor-immune landscape, we first divided the METABRIC samples into Th2-high and Th2-low groups based on GATA3 expression, and delineated the pattern of TILs in the two groups based on gene expression profile with CIBERSORT algorithm.