We also analyzed the methylation of the USP13 promoter in PAAD, HNSC, ccRCC and UCEC, and the results suggested that the USP13 promoter was hypermethylated in PAAD and ccRCC tumor tissues and hypomethylated in HNSC tumor tissues compared with normal tissue samples (Fig. 1K-N). The gene discussed is USP13; the disease is pancreatic adenocarcinoma.