In the present study, the IGF-1/IGFBP-3 ratio remained stable at 0.19 ± 0.06 with rhGH treatment, similar to the study by Gaddas et al. that reported a molar ratio of 0.19 ± 0.09 in children with PWS—well within the normal range [34]. The gene discussed is IGFBP3; the disease is Prader-Willi syndrome.