ERBB2 and breast cancer: In this study, we designed a cost-effectiveness analysis based on clinical data and compared three gBRCA testing strategies in all TNBC and HR-positive HER2-negative BC patients: (1) no gBRCA testing (no test); (2) selected gBRCA testing based on family history and genetic consultations (selected test) and (3) universal gBRCA testing for all TNBC and HR-positive HER2-negative BC patients (universal test).