For instance, a meta-analysis of 14 studies with 2015 patients in hepatocellular carcinoma found a positive correlation between high levels of CD8+ T lymphocytes and OS (HR 0.71; 95% CI 0.51–0.99; P = 0.04) and DFS (HR 0.66; 95% CI 0.47–0.92; P = 0.01) [17]. Here, CD8A is linked to hepatocellular carcinoma.