In our study, it will be interesting to analyze the correlations of the JAK2 allele burden with relevant clinical outcome data (such as thromboembolic complications or transformation to post-PV MF), given that the PV pts in this trial were mostly untreated and had been enrolled at an earlier disease timepoint, possibly rendering them more susceptible to JAKi treatment than the pts enrolled in the RESPONSE trials. Here, JAK2 is linked to acquired polycythemia vera.