Currently updated data further support the favorable safety profile of ADP-A2M4CD8, while also providing encouraging evidence of clinical activity in patients with MAGE-A4- positive unresectable or metastatic tumors, especially gastroesophageal and ovarian tumors, for which also, two phase 2 trials are to be initiated (Fang et al. 2022). Here, MAGEA4 is linked to metastatic neoplasm.