More precisely, IL-12 has been shown to have several effects on cancer stroma, namely extracellular matrix alterations (reduced matrix metalloproteinases (MMPs), vascular endothelial growth factor (VEGF), induction of type 1 T helper (Th1) polarisation, NK cells activation, negative effect in angiogenesis and endothelial adhesion molecules (Chmielewski and Abken 2012; Hsieh et al. 1993; Hung et al. 1998; Curtsinger et al. 2003). This evidence concerns the gene VEGFA and cancer.