CCL5 and neoplasm: Endogenous T-cells and therefore CAR-T cells typically express RANTES (Regulated upon Activation, Normal T Cell Expressed and Presumably Secreted) receptors (CCR1, CCR3, and CCR5) and the combination of CAR-T cells with the local delivery of CCL5-expressing oncolytic virus has improved persistence of CAR-T cells at tumor sites in preclinical models (Craddock et al. 2010; Kalmpatsa et al. 2020).