HLA alleles have been shown to be associated with ICI-induced pruritus (HLA-DRB1*11:01, OR 4.53, p = 0.002) colitis (HLA-DQB1*03:01, OR 3.94, p = 0.017)58, arthritis (HLA-DRB1*04:05, OR 8.6, p = 0.04)59, type 1 diabetes (HLA-DRB1*03 and HLA-DRB1*04 haplotypes)60 and pituitary irAE (81.8% HLA-DR15 vs 33.5% in healthy controls, p = 0.0014)61. This evidence concerns the gene HLA-DRB1 and Pruritus.