To investigate whether the biological function of KDM6B in gastric cancer depends on its enzymatic activity, we added 1 μM of GSK-J4, an inhibitor of the enzymatic activity of KDM6B, to gastric cancer cells, and the results showed that 1 μM GSK-J4 significantly inhibits the clonogenic ability of gastric cancer cells (Fig. 2B). The gene discussed is KDM6B; the disease is gastric cancer.