We also show a link between failures of the PrRP signaling and dysregulation of the MCH system, known to be involved in the pathomechanism of depression, anxiety, and PTSD (Chaki et al., 2005; Lagos et al., 2011; Torterolo et al., 2015; Concetti et al., 2020). This evidence concerns the gene PRLH and depressive symptom measurement.