Our lab has investigated each of these 3 components of the AV3V region and their individual roles in mediating the effects of chronic “AngII hypertension” and have reported that discrete lesions of each of these areas (SFO, OVLT and MnPO) attenuated or nearly abolished “AngII hypertension” (Collister & Hendel, 2005; Hendel & Collister, 2005; Ployngam & Collister, 2007; Vieira et al., 2010). The gene discussed is AGT; the disease is hypertensive disorder.