Based on further reports that the OVLT is a prominent central osmoreceptor, as it has been shown to be involved in mediating sympathetic nervous system activity in response to acute increases in plasma osmolality (Toney, Chen, Cato, & Stocker, 2003; Toney & Stocker, 2010), we tested the hypothesis that the OVLT is necessary for the full rise in arterial pressure in the “AngII‐salt induced hypertension” model. This evidence concerns the gene AGT and hypertensive disorder.