Pilot studies have demonstrated that NAC reduces disease activity in SLE.41 Although the ability of NAC to suppress disease activity in SLE was attributed to its ability to block mTOR activation in T cells,41 comparing the ability of NAC to suppress oxmtDNA production, ISG expression and disease activity in SLE and JDM could be an interesting focus of future studies. The gene discussed is MTOR; the disease is systemic lupus erythematosus.