EIF2AK3 and supranuclear palsy, progressive, 1: EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3), more commonly known as PERK (protein kinase R-like endoplasmic reticulum kinase), is a genetic risk factor for tauopathies: PSP (13, 14, 15) and AD (16, 17).