Conditions such as sleep deprivation or pulsed light exposure can disrupt circadian rhythm oscillations, thereby affecting the expression or transcriptional activity of clock genes, which in turn leads to a variety of pathologies, including accelerated aging, dementia, and vascular disease (Musiek et al., 2013), and clock genes including BMAL1, CLOCK, and retinoic acid‐related orphan receptor alpha (RORα) are involved in the regulation of immune and inflammatory cell function. Here, RORA is linked to dementia.