S10C) were also observed in MV411 cells (AML cells exhibited similar sensitivity to ACTR5 depletion as SNU475 cells in Fig. 1E), indicating that the ACTR5-directed regulation of CDKN2A may exist across multiple cancer types, extending the impact of the current study beyond HCC. The gene discussed is CDKN2A; the disease is acute myeloid leukemia.