CDKN2A and hepatocellular carcinoma: Our results revealed a significant reduction of H3K9me2 but not H3K27me3 at the CDKN2A TSS locus upon ACTR5 depletion (Fig. 2, F and G), indicating a role of ACTR5 in recruiting H3K9 epigenetic silencing of CDKN2A in HCC.