Similar to other NSAIDs, diclofenac inhibits prostaglandin synthesis by inhibiting cyclooxygenase (COX)‐1 and COX‐2.[56] Diclofenac inhibits COX‐2 with greater potency than COX‐1.[57] However, one study showed that NSAIDs do not require the presence of COX‐2 to treat cancer;[58] thus, we believe that diclofenac may suppress CD73 transcription in a manner independent of COX‐2. The gene discussed is NT5E; the disease is cancer.