In the canonical pathway, CD73 is thought to be anchored to the cell‐surface membrane by glycosylphosphatidylinositol (GPI), where it hydrolyzes AMP into adenosine and activates adenosine receptors.[5, 31] Most previous studies demonstrated that CD73 promoted tumor metastasis as a rate‐limiting enzyme for adenosine production, by signaling through adenosine receptors, A2AR and A2BR.[32, 33] In several recent studies, CD73 was shown to be present in the cytoplasm[19, 34] and to function in a nucleotidase‐independent manner. This evidence concerns the gene ADORA2A and neoplasm.