Studies indicate that CD73 is highly expressed in multiple human cancers and is well‐known to promote tumor immune evasion, and thus is considered as an immune checkpoint mediator.[5, 6, 7] Moreover, CD73 has been shown to be a crucial therapeutic target for cancer due to its involvement in tumorigenesis, metastasis, proliferation, apoptosis escape, angiogenesis, and resistance to chemotherapy.[8, 9, 10, 11, 12, 13, 14]. Here, NT5E is linked to cancer.