SLC8B1 and Cognitive impairment: In contrast, neuronal Nclx deletion negatively influenced novel object recognition performance (Figure 5f) without affecting the Y-maze test (Figure 5h), a result compatible with previous data indicating that increased mitochondrial Ca2+ in neurons secondary to NCLX defects is linked to cognitive impairment (Jadiya et al., 2019; Stavsky et al., 2021).