Then, we included the above factors in the multivariate analysis, and the independent risk factors for pulmonary hypertension were determined to be age (odds ratio (OR) 1.032; 95% confidence interval (CI) 1.020–1.043), DM (OR 1.942; 95% CI 1.317–2.863), Hb (OR 0.969; 95% CI 0.960–0.978), PLT count (OR 0.995; 95% CI 0.992–0.997), Scr (OR 1.001; 95% CI 1.000–1.002), LVDd (OR 1.043; 95% CI 1.020–1.067), LAD (OR 1.033; 95% CI 1.013–1.054), MPAD (OR 1.098; 95% CI 1.056–1.141) and LVEF (OR 0.946; 95% CI 0.931–0.962). The gene discussed is GSTM1; the disease is pulmonary arterial hypertension.