When comparing with PAM50 subtypes [27], the estrogen receptor (ER) positive breast tumors (Luminal A and Luminal B) were found in RankClusters 8 and 11, with the majority of Luminal A in RankCluster 8 and the majority of Luminal B in RankCluster 11 (Table 3). The gene discussed is ESR1; the disease is breast neoplasm.